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Acetyl Hexapeptide-3 200mg
In many different online sources, this peptide has been incorrectly referred to as Acetyl-Hexapeptide-3, which became a common, household name for it (this is why we still refer to it as such, to avoid confusing our customers), but it’s scientific name is acetyl hexapeptide-8 (also going under the original trade name Argireline).
This peptide is known for its water-binding and skin-restoring abilities; this is why it’s found such a wide application in the skincare industry.
$220.00
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Palmitoyl Tripeptide-5 200mg
$210.00(0 Reviews)
Due to their ability to interact with sensitive skin, cosmetic peptides started to stand out as one of the go-to ingredients in the skincare industry. Another thing making them stand out even more, is the fact they are highly potent even at lower dosages.
One such peptide is palmitoyl tripeptide-5, which you can buy at Peptide.Shop.
What Is Palmitoyl Tripeptide-5?
This is a synthetic peptide which mimics the sequence of the protein Thrombospondin I (TSP-1) fragment, presenting the sequence N-(1-oxohexadecyl)-L-lysyl-L-valyl-L-lysine.
Initially, this tripeptide was produced with the help of solid-phase synthesis. But, since this mode of production caused significant cost and pollution to the environment, two different liquid methodologies were introduced.
What Does It Do?
Palmitoyl Tripeptide-5 was hypothesized to reduce metalloproteases (MMP’s) expression and pro-inflammatory cytokine synthesis; these effects result in vasodilation and increased capillary permeability.
This is why this cosmetic peptide was first used as an ingredient in products designed to reduce skin redness in type I rosacea. It was also used in anti aging cosmetic products, formulas for sensitive skin, as a type I and II collagen synthesis promoter, as well as a melanin production inhibitor (aimed at reducing tyrosinase activity).
How Effective Was Palmitoyl Tripeptide-5?
As mentioned through the text, for some of these studies we only have the basic information and can not conclusively say how effective this tripeptide really was. Luckily, we have one animal study done in vitro, that showed Palmitoyl Tripeptide-5 therapy significantly decreased collagen breakdown process.
References:
https://pmc.ncbi.nlm.nih.gov/articles/PMC8400021/
Tao Y., Chen J., Wang X. Method for Efficiently Preparing Palmitoyl Tripeptide-5 Based on Activated Ester. CN110423264A. 2020 Dec 1;
Ziegler H., Heidl M., Imfeld D. Tripeptides and their derivatives for cosmetic applications for improving skin structure. WO2004099237A1. 2004 Nov 18;
DSM Launches Regu-Cea. [(accessed on 7 May 2021)]; Available online: https://www.happi.com/contents/view_breaking-news/2009-04-22/dsm-launches-regu-cea/
Milanello S. REGU®-CEA: Approccio multifunzionale contro i sintomi della rosacea. Kosmetica. 2009:56–58. [Google Scholar]
Liao Y., He L., Liu X., Liu Y. Composition for Repairing Sensitive Skin, and its Application in Cosmetic. CN109010113A. 2018 Dec 18;
Lu X., Dai C., He H., Liang J., Tang Z. Multifunctional Toning Lotion and its Preparation Method. CN111632001A. 2020 Sep 8;
Ji X., Lin J., Wang L. Preparation Method of Dried Facial Mask Comprising Ceramide-2 and Traditional Chinese Medicine Extract for Caring Skin. CN109350591A. 2021 May 25;
Avcil M., Akman G., Klokkers J., Jeong D., Çelik A. Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study. J. Cosmet. Dermatol. 2020;19:328–337. doi: 10.1111/jocd.13009.
SNAP-8 200mg
$175.00(0 Reviews)
SNAP-8 is a mimetic of the N-terminal end of SNAP-25 (SyNaptosome-Associated Protein). SNAP-8 competes with its 25 counterpart for a position within the SNARE complex and, by doing so, changes its formation. SNARE complex (SNAP REceptors complex) primary role is to mediate the fusion of vesicles with the target membrane. Some of these vesicles contain neurotransmitters responsible for botulism and tetanus, suggesting that the SNARE complex affects muscle contractions and prevents fine lines from being formed.
SNAP-8 is a synthetic peptide that mimics the effects of botulinum. Unlike botulinum which stops the release of chemical acetylcholine (which makes the muscles contract), SNAP-8 disrupts the SNARE complex. This will, then, prevent the release of acetylcholine and prompt temporary muscle relaxation.
Pentapeptide-18 200mg
$210.00(0 Reviews)
Pentapeptide-18 belongs to the group of neurotransmitter peptides and is associated with the SNAP-25 receptor protein (SyNaptosome-Associated Protein, 25 kDa). This receptor protein is involved in the release of acetylcholine and the formation of SNARE (SNAP receptors) complex.
Pentapeptide-18 affects the neuromuscular synapses and, by binding to these synapses, it closes up the calcium channels, which results in the reduction of acetylcholine release. Acetylcholine is responsible for muscle contractions and the formation of wrinkles; so, by blocking it, researchers believe they can affect the formation and the severity of wrinkles.
Some added Pentapeptide-18’s benefits, that the researchers noticed, was its ability to hydrate the skin and improve its firmness. Of course, more research is still needed, but the initial findings are pointing in the right direction.
Tripeptide-29 200mg
$200.00(0 Reviews)
Tripeptide-29 is a synthetic peptide which utilizes a three-chain amino acid sequence that mimics one of the basic building blocks of collagen. When speaking of collagen, we should point out that it’s a natural protein found in skin and all internal organs; but it’s not only a structural protein, it also plays a role in cell adhesion, tissue regulation and healing.
Tripeptide-29, thus, acts as a building block of large collagen molecules and may impact multiple physiological features.
Palmitoyl Tripeptide-1 (Pal-GHK) 200mg
$190.00(0 Reviews)
Pal-GHK, also called Palmitoyl Tripeptide-1, is a synthetic peptide, a collagen fragment presenting the sequence N-(1-oxohexadecyl)glycyl-L-histidyl-L-lysine). The GHK sequence of this peptide consists of three amino acids (Gly-His-Lys), commonly found in plasma, which is attached to a palmitic acid molecule.
The importance of the added palmitic group is in increasing lipophilicity (the ability to dissolve in fats, oil, lipids) which allows it to penetrate the stratum corneum of the epidermal barrier better. This makes the peptide as a whole, more compatible with the lipid-rich environment, better overall penetration and absorption.
Pal-GHK Action and Potential Application
Pal-GHK, or palmitoyl tripeptide-1, has been studied for its potential effects on collagen and overall skin health and pigmentation. Scientists are mainly interested in its ability to stimulate collagen production and boost blood vessel growth.
The “success” of Pal-GHK peptide relies heavily on the body’s natural ability to initiate collagen production when it gets damaged. When collagen in our body gets damaged, whe are left with fragments which then signal our body to start producing more of it. And this very process was identified in 1988 when it was found that the GHK section is that actual fragment that signals collagen production response.
And the Pal section, as we already said, was designed merely as a “vehicle” which allows for the rest of the peptide compound to penetrate the skin barrier and better dissolve in the tissue below.
Even though we are still missing more comprehensive, human studies, animal models showed Pal-GHK was able to protect the skin better, increase collagen production, as well as elastin, and restore moisture and fullness. Besides acting on its own, Pal-GHK peptide was also shown to be an amazing complementary ingredient, able to boost the effectiveness of other skin care products and further improve their skin care, reduce wrinkles and minimize photodamage.
References:
https://febs.onlinelibrary.wiley.com/doi/10.1016/0014-5793%2888%2980509-X
https://pmc.ncbi.nlm.nih.gov/articles/PMC8400021/
https://onlinelibrary.wiley.com/doi/10.1046/j.1467-2494.2000.00010.x
GHK-Cu 200mg
$200.00(0 Reviews)
GHK-Cu is also known as the human copper tri-peptide. GHK-Cu is a naturally occurring peptide, and it’s particularly interesting to researchers due to its anti-inflammatory and antioxidant properties and the fact it gets released from tissue after injury.
Even though it was initially thought that GHK-Cu only binds copper ions, the prevailing idea now is that it can up and down regulate genes involving injuries and stress response.
Pal-AHK 200mg
$180.00(0 Reviews)
Also called Palmitoyl Tripeptide-3, Pal-AHK is a synthetic peptide which consists of three amino acids – Alanine, Histidine and Lysine, with the addition of palmitoyl group. Just like when we were talking about Pal-GHK, the added palmitoyl group serves as a “vessel” that aids the bundled amino acids to penetrate the stratum corneum and enter the tissue. This added Pal group makes the entire compound fat soluble, increasing the overall absorption and effectiveness.
Pal-AHK Research Application
We still don’t have many human studies, so we have to rely heavily on animal ones. These animal studies tell us that Pal-AHK has the ability to activate fibroblasts (a type of cell which contributes to the formation of the connective tissue), increasing the rate of extracellular matrix production within the skin.
Since the extracellular skin matrix is abundant in collagen and elastin cells, by boosting it, Pal-AHK raises collagen and elastin levels, improving skin appearance and tightness.
Some of these animal studies also pointed out that the Pal-AHK molecule affects the production of vascular endothelial growth factor (VEGF), crucial in new blood vessels production. Increased vascularity in the skin improves its physical appearance and rejuvenates in.
Speaking of skin appearance, we already talked about Pal-AHK’s ability to boost collagen and elastin levels; this, coupled with increased skin penetration, allows for wrinkles and fine lines appearance reduction, improvements in the appearance in age spots, skin tone and texture, as well as improvements in the overall skin smoothness. Of course, we’re only talking about animal models, we have yet to see some conclusive human studies.
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